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Graphene as a powerful inorganic material such as excellent conductivity and  ideal mechanical strength has recently been extensively utilized to develop  flexible strain sensors. However, graphene-based strain sensors usually suffer  from the deficiencies of stretchability, sensitivity, and sensing range, which  can restrict their applications in wearable devices. Here, a novel strain sensor  is designed by integrating graphene/ecoflex film and meandering zinc wire  into the flexible base. The constructed strain sensor not only possesses high  stretchability of up to 150% strain but can also self-generates current signals  from redox-induced electricity, where the stable current and voltage signals of  about 75 µA and 0.83 V can be obtained, respectively. Furthermore, the selfpowered sensor presents a broad and linear sensing range of 25% to 150%  strains and a fast response time of less than 0.11 s. Attached on human body,  the sensor has been utilized to realize the motion detection of knee joint.